|
|
(S)-3-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA
|
4.1.3.4
hydroxymethylglutaryl-CoA lyase
|
–
|
| |
BRENDA:
BR395;
BS416230
KEGG:
R01360
MetaCyc:
HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
SABIO-RK:
1564
|
|
|
|
3-methylcrotonoyl-CoA + HCO3- + ATP <=> trans-3-methylglutaconyl-CoA + ADP + phosphate + H+
|
6.4.1.4
methylcrotonoyl-CoA carboxylase
6.4.1.5
geranoyl-CoA carboxylase
|
–
–
|
| |
BRENDA:
BR156
KEGG:
R04138
MetaCyc:
METHYLCROTONYL-COA-CARBOXYLASE-RXN
SABIO-RK:
3859
|
|
|
|
L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate
|
2.6.1.1
aspartate transaminase
2.6.1.2
alanine transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.6
leucine transaminase
2.6.1.67
2-aminohexanoate transaminase
2.6.1.9
histidinol-phosphate transaminase
|
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR47691
KEGG:
R01090
MetaCyc:
BRANCHED-CHAINAMINOTRANSFERLEU-RXN
SABIO-RK:
1352
|
|
|
|
4-methyl-2-oxopentanoate + CoA + NAD+ <=> isovaleryl-CoA + CO2 + NADH
|
1.2.1.25
branched-chain alpha-keto acid dehydrogenase system
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
|
–
–
|
| |
BRENDA:
BS231865
KEGG:
R01651
MetaCyc:
2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN
SABIO-RK:
1788
|
|
|
|
(S)-3-hydroxy-3-methylglutaryl-CoA <=> H2O + trans-3-methylglutaconyl-CoA
|
4.2.1.18
methylglutaconyl-CoA hydratase
|
–
|
| |
BRENDA:
BR3388
KEGG:
R02085
MetaCyc:
METHYLGLUTACONYL-COA-HYDRATASE-RXN
SABIO-RK:
2095
|
|
|
|
isovaleryl-CoA + oxidized_electron_transfer_flavoprotein + H+ <=> 3-methylcrotonoyl-CoA + reduced_flavodoxin
|
1.3.8.4
isovaleryl-CoA dehydrogenase
|
–
|
| |
MetaCyc:
RXN0-2301
|
|
